Deni Hardiansyah, Dr. sc. hum

xr:d:DAFfOHLjVkA:5,j:3329681061067498048,t:23063008

SKETSA BIOGRAFIS

Dr. sc. hum. Deni Hardiansyah
Dosen Madya,
Kelompok Penelitian Fisika Medis dan Biofisika,
Jurusan Fisika, Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA),
Universitas Indonesia, Indonesia.

Gedung F (Jurusan Fisika), FMIPA UI, Universitas Indonesia, Depok, 16424
Email:
(University): denihardiansyah@ui.ac.id
(Faculty): denihardiansyah@sci.ui.ac.id

Tentang

Dr. Hardiansyah adalah Lektor Kepala di Departemen Fisika FMIPA, Universitas Indonesia. Dr. Hardiansyah meraih gelar doktor di Universitas Heidelberg, Jerman, dengan fokus pada penerapan model farmakokinetik berbasis fisiologis (PBPK) untuk meningkatkan dosimetri individu dalam Radioterapi Molekuler. Selain Radioterapi Molekuler, ia juga menerbitkan beberapa makalah di bidang pencitraan molekuler/fungsional. Setelah meraih gelar doktor, ia bekerja sebagai postdoc dan staf di College of Pharmacy, University of Kentucky, AS, di bidang ilmu farmasi. Secara umum, ia telah melakukan penelitian dalam berbagai aspek dosimetri kedokteran nuklir, pencitraan dan pemodelan PKPD obat.

2013 – 2016 Dr. sc. hum. (2.5 years), Heidelberg University, Germany
2011 – 2013 MSi. (1.5 years), Institut Teknologi Bandung, Indonesia
2006 – 2010 SPd. (3 years and 10 months), Universitas Pendidikan Indonesia, Indonesia

2013-2016 BPPLN Scholarships for Doctoral Degree from DIKTI
2011-2013 BPPDN Scholarships for Master Degree from DIKTI
2006-2010 PSF Scholarships for Bachelor Degree from Putera Sampoerna Foundation

2023-2026 Project managers for SDG DAAD Grant “Entwicklung der Medizinischen Physik in Lehre und Forschung in Indonesien”
2024 The 1st winner of the Tomio Inoue award 2024
2024 Lecturer at SIGFRID EFOMP school webinar 2024
2024 Co-lead of Focus Group 8 of SIGFRID EFOMP (https://www.efomp.org/index.php?r=pages&id=sig-frid)
2024 Top Rated Oral Presentation at EANM Conference 2024
2024 International Best Abstract at the SNMMI Conference 2024, Toronto, Canada
2023 Keynote speaker at SINAFI Conference 2023, Bandung, Indonesia
2023 International Best Abstract at the SNMMI Conference 2023, Chicago, USA
2023 Best Presenter at 28th ITSF Seminar on Science and Technology
2022 Invited Expert at IAEA RTC on Theranostic and Neurology in Diagnostic and Treatment of NCDs for Radiologist and Nuclear Medicine Physicians
2022 Organizer of GC-AAPM TACTIC 2023
2022 World Class Professor Grant from DIKTI
2021 Science & Technology Research Grant 2022 from Indonesian Toray Science Foundation (ITSF) for Molecular Radiotherapy Research Project.
2021 International Best Abstract at the SNMMI Virtual Conference 2021, USA
2020 Top Rated Oral Presentation at EANM Conference 2020
2018-2019 Top Downloaded Paper 2018-2019 Award in Clinical and Translational Science Journal
2017 International Best Abstract at the SNMMI Conference 2017, Denver, USA
2016 Travel Award recipient from Heidelberg University to attend SNMMI Conference 2016, San Diego, USA

2024-now Institution: ICO Nantes Universite, France. Collaborators: Nicholas Vermenot, and Ludovic Ferrer.
2023-now Institution: Universitaetklinikum Freiburg, Germany. Collaborators: Prof. Michael Mix, Dr. Felix Kind, and Dr. Juri Ruf.
2023-now Institution: OPEN DOSE Developer, INSERM, France. Collaborators: Prof. Manuel Bardies, and Jose Ferguso MSc.
2023-now Institution: Radboud University Medical Center, The Netherlands. Collaborators: Prof. Mark Konijnenberg, and Dr. Steffie B. Peters.
2023-now Institution: Universitaetklinikum Wuerzburg, Germany. Collaborators: Prof. Michael Lassmann, and Dr. Heribert Haencheid.
2022-2024 Institution: NewGround Pharm. Consulting LLC, USA. Collaborators: Prof. Dr. Chee M. Ng.
2020-now Institution: TU Munich, Germany. Collaborators: Prof. Matthias Eiber.
2019-now Institution: Ulm University, Germany. Collaborators: Prof. Gerhard Glatting, Dr. Peter Kletting, Prof. Ambros Beer, and Dr. Elham-Yousefzadeh.

2019-now Lecturer at Physics Department, FMIPA, Universitas Indonesia, Indonesia
2016-2019 Postdoctoral scholars and Staff at University of Kentucky, USA

Fisika Medis
Kedokteran Nuklir
Radioterapi Molekuler/Terapi Radiofarmasi
Pemodelan Efek Campuran Non-Linear (NLME)
Terapi Radionuklida Reseptor Peptida (PRRT)
Terapi Antigen Membran Spesifik Prostat (PSMA)
Pencitraan Molekuler/Fungsional
Ilmu Farmasi
Pemodelan Farmakokinetik Berbasis Fisiologis (PBPK)
Pemodelan Farmakologi Sistem Kuantitatif (QSP)

Research Gate
Linkedin
Google Scholar
Scopus

Hardiansyah D, Ng CM. Farmakologi Kuantitatif dan Strategi Terapi Individual dalam Pengembangan Protein Terapi untuk Penyakit Peradangan yang Dimediasi Imun. Bab: Pendekatan Farmakologi Kuantitatif untuk Memilih Dosis Optimal dan Mempelajari Faktor-Faktor Penting dalam Menentukan Disposisi Antibodi Monoklonal Terapi pada Subjek Pediatrik – Beberapa Pertimbangan. Maret 2019. Wiley, ISBN: 978-1-119-28919-7.

Research Gate
Linkedin
Google Scholar
Scopus
  1. Patrianesha BB, Peters SMB, Hardiansyah D$, Ritawidya R, Privé BM, Nagarajah J, Konijnenberg MW, Glatting G. Single-time-point dosimetry using model selection and the Bayesian fitting method: A proof of concept. Phys Med. 2025. 129. 104868. $Corresponding author
  2. Subangun RM*, Hardiansyah D$*, Ibrahim RFI, Patrianesha BB, Hidayati NR, Beer AJ, Glatting G. Few-time-points time-integrated activity coefficients calculation using non-linear mixed-effects modeling: Proof of concept for [111In]In-DOTA-TATE in kidneys. Phys Med. 2025. 129. 104865.*equal contribution, $Corresponding author
  3. Hardiansyah D, Yousefzadeh-Nowshahr E, Kind F, Beer AJ, Ruf J, Glatting G, Mix M. Single-Time-Point Renal Dosimetry Using Nonlinear Mixed-Effects Modeling and Population-Based Model Selection in [177Lu]Lu-PSMA-617 Therapy. J Nucl Med. 2024. 65(4),566-572.
  4. Jundi AF, Naqiyyun MD, Patrianesha BB, Mu’minah IAS, Riana A., Hardiansyah D. Uncertainty Analysis of Time-Integrated Activity Coefficient in Single-Time-Point Dosimetry Using Bayesian Fitting Method. Nucl Med Mol Imag. 58(3),120-128.
  5. Ivashchenko OV, O’Doherty J,Hardiansyah D, Cremonesi M, Tran-Gia J, Hippeläinen E, Stokke C, Grassi E, Sandström M, Glatting G, Time-Activity data fitting in molecular Radiotherapy: Methodology and pitfalls. Physica Medica. 117(2024).
  6. Hardiansyah D, Riana A, Beer A, Glatting G. Single-time-point dosimetry using model selection and nonlinear mixed-effects modelling: a proof of concept. EJNMMI Phys. 10: 12 (2023)
  7. Hardiansyah D, Riana A, Eiber M, Beer A, Glatting G. Population-based model selection for an accurate estimation of time-integrated activity using non-linear mixed-effects modeling. Z Med Phys. In print 20 Feb 2023.
  8. Hardiansyah D, Riana A, Beer A, Glatting G. Single-time-point estimation of absorbed doses in PRRT using a non-linear mixed-effects model. Z Med Phys. 2023;33(1), 70-81.
  9. Hardiansyah D, Ng CM. Minimal Physiologically-based Pharmacokinetic Model to Investigate the Effect of Charge on the Pharmacokinetics of Humanized anti-HCV-E2 IgG Antibodies in Sprague-Dawley Rats. Pharm Res. 2022;39:481-96.
  10. Hardiansyah D, Riana A, Kletting P, Zaid NRR, Eiber M, Pawiro SA, Beer AJ, Glatting G. A population-based method to determine the time-integrated activity in molecular radiotherapy. EJNMMI Phys. 2021 Dec 14;8(1):82.
  11. Hardiansyah D, Kletting P, Begum NJ, Eiber M, Beer AM, Pawiro SA, and Glatting G. Important pharmacokinetic parameters for individualization of (177) Lu-PSMA therapy: A global sensitivity analysis for a physiologically-based pharmacokinetic model. Med Phys. 48:556-568 (2021).
  12. Hardiansyah D*$, Attarwala AA*, Romano C, Jimenez-Franco LD, Roscher M, Wangler B, and Glatting G. Performance assessment of the ALBIRA II pre-clinical SPECT S102 system for (99m)Tc imaging. Ann nucl med. 35:111-120 (2021). *equal contribution.$corresponding author.
  13. Hardiansyah D, Ng CM. Quantitative Systems Pharmacology Model of Chimeric Antigen Receptor T cell Clin Transl Sci. 2019;12(4):343-349.
  14. Hardiansyah D, Ng CM. Minimal Physiologically-based Pharmacokinetic Model to investigate the Effect of pH Dependent FcRn Affinity and the Endothelial Endocytosis on the Pharmacokinetics of Anti-VEGF Humanized IgG1 Antibody in Cynomolgus Monkey. Eur J Pharm Sci. 2018;125:130-141.
  15. Hardiansyah D, Ng CM. Effects of the FcRn developmental pharmacology on the pharmacokinetics of therapeutic monoclonal IgG antibody in pediatric subjects using minimal physiologically-based pharmacokinetic modelling. mAbs. 2018;10(7):1144-1156.
  16. Hardiansyah D, Ng CM. Two-Pore Minimum Physiologically-based Pharmacokinetic Model to Describe the Disposition of Therapeutic Monoclonal IgG Antibody in Humans. Pharm Res. 2018.35(3):47.
  17. Hardiansyah D, Maass C, Attarwala AA, Müller B, Kletting P, Mottaghy FM, Glatting G. The Role of Patient-Based Treatment Planning in Peptide Receptor Radionuclide Therapy. Eur J Nucl Med Mol Imaging. May 2016;43(5):871-880.
  18. Hardiansyah D*, Attarwala AA*, Romano C, Roscher M, Molina-Duran F, Wangler B. Glatting G. A method for point spread function estimation for accurate quantitative imaging. IEEE Transactions on Nuclear Sciences. 2018. 65(3):961-969 *equal contribution.
  19. Hardiansyah D*, Attarwala AA*, Kletting P, Mottaghy FM, Glatting G. Prediction of time- integrated activity coefficients in PRRT using simulated dynamic PET and a pharmacokinetic model. Physica Medica. 2017;42:298-304. *equal contribution.
  20. Hardiansyah D, Begum NJ, Kletting P, Mottaghy FM, Glatting G. Sensitivity Analysis of a PBPK Model Used for Treatment Planning in Molecular Radiotherapy. Cancer Biother Radiopharm. Aug 2016;31(6):217-224.
  21. Hardiansyah D, Guo W, Kletting P, Mottaghy FM, Glatting G. Time-integrated activity coefficients estimation for radionuclide therapy using PET and a pharmacokinetic model: A simulation study on the effect of sampling schedule and noise. Med Phys, 2016. 43(9): p. 5145.
  22. Hardiansyah D, Guo W, Attarwala AA, Kletting P, Mottaghy FM, Glatting Treatment planning in PRRT based on simulated PET data and a PBPK model. Determination of accuracy using a PET noise model. Nuklearmedizin. 2017. 56(1):23-30.
  23. Maaß C, Rivas JRA, Attarwala AA, Hardiansyah D, Niedermoser S, Litau S, Wängler C, Wängler B, Glatting G. Physiologically based pharmacokinetic modeling of 18F-SiFAlin- Asp3-PEG1-TATE in AR42J tumor bearing mice. Nucl Med Biol. Apr 2016;43 (4):243-246.
  24. Maaß C, Sachs JP, Hardiansyah D, Mottaghy FM, Kletting P, Glatting G. Dependence of treatment planning accuracy in peptide receptor radionuclide therapy on the sampling schedule. EJNMMI Res. Dec 2016; 6(1):30.
  25. Attarwala AA, Karanja YW, Hardiansyah D, Romano C, Roscher M, Wängler B, Glatting G. Investigation of the Imaging Characteristic of the ALBIRA II Small Animal PET Imaging System for 18F, 68Ga and 64 Zeitschrift für Medizinische Physik. 2017. 27(2):132-144.
 
  1. NR Hidayati, N Nuraeni, D Hardiansyah, SA Pawiro. Estimation of human absorbed radiation dose of radiopharmaceuticals based on animal biodistribution data: A review from last decade. AIP Conference Proceedings. 2024. 3210(1)
  2. Jadidan A, Ananda FD, Muhammad Z, Hardiansyah D. Mathematical Model to calculate the total number of decays in peptide receptor radionuclide therapy using nonlinear mixed effect modeling. 2023  Phys.: Conf. Ser.2596 012033
  3. Pratiwi N, Riana A, Hardiansyah D. Calculation of the total number of radiation decay of radiolabelled octretotate using non-linear mixed effect models. 2023 ITM Web of Conferences.61 01023
  4. IR Apriani, DA Adlina, D Hardiansyah. Mathematical Model to Calculate the Total Number of Radiation Decays of Radiolabelled-Pembrolizumab in Mice. 2022  Phys.: Conf. Ser.2377 012029
  5. AD Widyanugraha, N Atikah, D Hardiansyah. Estimation of The Main Effect and Total Effect of a PBPK Model Based on The Uncertainty of Individual Parameter for Treatment Planning in PSMA Therapy. IOP Conference Series: Earth and Environmental Science. 2021 913 (1), 012101
  6. N Atikah, A Riana, A Dwi, Z Anwari, D Hardiansyah. Model Selection in Peptide-receptor Radionuclide Therapy for an Accurate Determination of Time Integrated Activity Coefficients. Journal of Physics: Conference Series 2019 (1), 012079
  7. A Jadidan, MZ Anwari, A Riana, YW Sari, D Hardiansyah. Biodistribution study of lutetium hydroxyapatite (177Lu-HA) for liver cancer therapy. ICSPMB Conference 2020. AIP Conference Proceedings2346 (1), 030001
  8. M Hasril, M Luthfy, A Riana, AN Ittaqa, SA Pawiro, D Hardiansyah. Study the effect of the physiological parameters to the optimal administration of lysine/arginine during peptide receptor radionuclide therapy (PPRT) using a physiologically-based pharmacokinetic (PBPK) model. ICSPMB Conference 2020. AIP Conference Proceedings2346 (1), 030004.
  9. MZ Anwari, TS Humani, NR Hidayati, D Hardiansyah. Effect of different radiopharmaceutical drug to the performance of translation methods of TIACs from mice to human. ICSPMB Conference 2020. AIP Conference Proceedings2346 (1), 030005
  10. LD HAM, Misrawati, AN Ittaqa, A Riana, D Hardiansyah. Study of the most important physiologic parameter using GSA with sobol method and a PBPK model for individualization of peptide-receptor radionuclide therapy. SNF Conference 2020. AIP Conference Proceedings2320 (1), 050030.
  11. A Riana, SA Pawiro, D Hardiansyah. Study of population and covariate model in physiologically based pharmacokinetics model used for treatment planning in peptide receptor radionuclide therapy. SNF Conference 2020. AIP Conference Proceedings2320 (1), 050015.
  12. AN Ittaqa, SA Pawiro, A Riana, LDHA Mas’udi, D Hardiansyah. Estimation of main and total effect of PBPK parameters in Meningioma patients. ICTAP 2020. Journal of Physics: Conference Series1816 (1), 012101.
  13. Hidayati NR, Hardiansyah D, Glatting G. Effect of Deviation in Image Quantification for Internal Dosimetry Assessment in Radionuclide Therapy. Research and Development on Nanotechnology in Indonesia. ISSN: 2356-3303. p. 49-51. V2. 2015.
  14. Hardiansyah D, Male S, Haryanto F. Study the Sensitivity of Dose Calculation in PRISM Treatment Planning System Using Monte Carlo Simulation of 6 MeV Electron Beam. SEACOMP 2014. AIP Conf. Proc. 1615, 213 (2014).